It mainly acts as a filter for purifying the blood, removing microbes and worn out or damaged red blood cells. The spleen is a very important organ in chinese medicine. In western medicine, we would see an organ according to its immediate function only. Each compartment has its own structure, cell population, and functions. Underneath the peritoneum is the capsule of the spleen, encasing its parenchyma. Patapis 3rd department of surgery, national and kapodistrian university of athens, medical school, attikon university hospital of athens, greece abstract tumors of the spleen are rare compared to the incidence of such tumors in other parenchymatous organs.
Since the spleen is involved in so many bodily functions, it is vulnerable to a range of disorders. Histological studies on the spleen of large white yorkshire pig sus scrofa article pdf available in journal of entomology and zoology studies 601. Figure 1 spleen accessory in a male b6c3f1n mouse from a chronic study. The spleen plays multiple supporting roles in the body. Spleen birte steiniger, university of marburg, marburg, germany the spleen is a secondary lymphoid organ present in all vertebrates. On the structure and use of the spleen internet archive. Sh practical lymphatic structure and organs embryology. Spleen structure the white pulp is circular in structure and is made up mainly of lymphocytes. The outermost layer of the splenic capsule is composed of mesothelial cells, which may not be evident on histologic section. The complete spleen structure, function, and clinical. Nurturing the spleen, explaining its function in chinese medicine. Pleural cavity separates spleen and diaphragm from the rib.
The spleen is delivered to the midline by means of blunt and sharp dissection of the areolar plane between the kidney and the pancreas. Light and electron microscopic observations on the spleen and the. The spleen is the largest single mass of lymphatic tissue in the body. The spleen is a soft, spongy organ of the lymphatic system. Two months postsplenectomy, the patient had clinically. Jun 23, 2019 the spleen is the largest organ of the lymphatic system. Dec 12, 2015 definition, structure and function of spleen 0 0 saturday, december 12, 2015 edit this post welcome to the science lovers, a simple blog to share knowledge with full sincerity. The spleen in local and systemic regulation of immunity. Spleen lies in between the fundus of the stomach and the diaphragm. Learn about spleen location, structure, functions and disorders at kenhub. The spleen has a dense connective tissue capsule, which contains trabeculae running into the interior of the spleen forming incomplete compartments as in the thymus. It functions in a manner similar to the nodules of the lymph node.
The splenic red pulp serves mostly to filter blood and recycle iron from aging red blood cells. A nodule of splenic tissue accessory spleen arrow is connected to the spleen via a mesenteric attachment arrowhead. The red pulp surrounds the white pulp and contains mainly red blood cells and macrophages. The structure of the spleen enables it to remove older erythrocytes from the circulation and leads to the. Histology of the spleen 101 wealth of knowledge about the structure and function of the different compartments in the rodent spleen. A lot of people think of the spleen the way it is seen in western medicine, which is.
This is also reflected in its embryological development, which. However, its size is not indicative of splenic involvement with hodgkin lymphoma. Major functions of the spleen include removing abnormal blood cells and making components of the immune system. Its immunological and haematological functions are being well realized nowadays. These include the white pulp with tcell areas and bfollicles, the nonfiltering lymphoid areas of the red pulp, the border between red and white pulp the perifollicular zone, the red pulp cord. Its network of trabeculae, blood vessels and lymphoid tissue provides an environment in which white blood cells lymphocytes proliferate while old damaged red blood cells erythrocytes are recycled. Spleen structure and function, splenic blood circulation, immune functions of spleen, splenomegally introduction the spleen is located in the left hypochondriac region of abdomen between the fundus of the stomach and diaphragm. Learn vocabulary, terms, and more with flashcards, games, and other study tools. With the spleen retracted medially, the phrenicocolic ligament is incised. The spleen combines the innate and adaptive immune system in a uniquely organized way. Pdf normal structure, function, and histology of the spleen. Red pulp is composed of splenic cords cords of billroth and a large volume of venous sinuses, which gives the structure a red appearance. It is an important organ for keeping bodily fluids balanced, but it.
Large trabeculae originate at the hilum, on the medial surface of the spleen. Summary the microanatomical structure of the spleen has been primarily described in mice and rats. Spleen lien is the largest lymphoid tissue in the body and specialised, beenshaped organ for filtering blood. It is similar in function to the cells of the liver. Acts as a giant lymph node, scanning erythrocytes, platelets and antigens. Structure, function, and clinical disorders under the title of the spleen in 1990, there has appeared a wealth of new information that now demands incorporation into the diagnosis and management of patients with splenic disorders. The spleen is an organ found in virtually all vertebrates. Zebra spleen, also referred to as psychedelic spleen or more correctly inhomogeneous splenic enhancement, refers to the transient heterogeneous parenchymal enhancement of the spleen during the arterial or early portal venous phases of contrast enhancement in ct, mri, or ultrasound imaging. Like the lymph node, the human spleen is a highly compartimentalized organ. Definition, structure and function of spleen science lovers. The spleen is surrounded by a capsule composed of dense fibrous tissue, elastic fibers, and smooth muscle. The microscopic structure of the spleen has been most thoroughly. In humans, it is about 12 cm long, 7 cm wide, and 3 cm in thickness, and weighs.
May 17, 2020 the spleen is the largest organ of your lymphatic system, a subdivision of the immune system. The spleen is surrounded by a capsule of dense connective tissue from which emerge trabeculae, which divide the parenchyma, or splenic pulp, into incomplete compartments. The morphological variations of the human spleen key words. The spleen is 1 by 3 by 5 inches 3 by 8 by cm, weighs approximately 7 oz 200 g, and lies between the 9th and 11th ribs on the lefthand sid. Jun 25, 2019 the spleen is an organ found in almost all vertebrate animals. The spleen is commonly enlarged on physical examination or by 99m tcsulfur colloid scan. The spleen is the largest lymphatic organ in the body. The capsule of the spleen consists of dense irregular fibroelastic tissue. The spleen is the largest organ in the lymphatic system. Disorders of the spleen include splenomegaly, hypersplenism and splenic rupture. Figure 2 spleen accessory in a male b6c3f1 mouse from a chronic study higher magnification of figure 1. It is structurally complex and has a number of different functions such as immunological monitoring of bloodborne antigens, storage of blood and destruction of aged or abnormal blood cells. Pdf histological studies on the spleen of large white.
The spleen is the largest accumulation of lymphoid tissue in the body. The spleen has more to do with the destruction of old blood cells and the production of certain types of white blood cells. The spleen is located on the left side of the abdomen, under the ribs. Splenomegaly, hypersplenism, and hereditary disorders with. Normal structure, function, and histology of the spleen. It is a highly vascular haemopoietic organ situated in the left hypochondrium directly beneath the. Lies just beneath the left half of the diaphragm close to 9,10 and 11 ribs and on the left side of abdomen. The structural organiza tion and multicellular composition of the.
Normal structure, function, and histology of the spleen mark f. Being an intraperitoneal organ, the spleen is covered by a layer of visceral peritoneum. In % of cases, the spleen is the only site of subdiaphragmatic disease. The fine structure of the following leucocytes, namely lymphoid cells, reticular cells, macrophage, haemocytoblasts, plasma cells and neutrophilic, basophilic. It acts as a filter for blood as part of the immune system.
The spleen is an important lymphatic organ in the human body. These include the white pulp with tcell areas and bfollicles, the nonfiltering lymphoid areas of the red pulp, the border between red and white pulp the perifollicular zone, the red pulp cord tissue and sinuses, and the perivascular rim. The spleen, in healthy adult humans, is approximately 7 centimetres 2. The spleen in western medicine is an organ on the outside of the pancreas. Lymphocytes produced in the spleen fight disease causin. In this article we will discuss about the structure of spleen with the help of suitable diagram. The structure of the spleen is such that two compartments can be distinguished. The spleen is located on the left side of the abdomen. The spleen is soft, highly vascular and dark purple in colour. The surgeon and the spleen itp low platelet, normal bone marrow, abscess of other causes increased platelet destruction mediated by autoantibodies to platelet membrane antigens that results in platelet phagocytosis by the spleen 72% pts 10yrs are female, 70% of affected females less than 40yrs.
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